By T.K. Ghose ,A. Fiechter, N.Blakebrough
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Additional info for Advances in Biochemical Engineering, Volume 010 : Immobilized Enzymes I
The proximity between the reacting enzymes results in a more rapid response initially and importantly a higher sensitivity towards low concentrations o f L-tryptophan. Aspartate Amino Transferase and Malate Dehydrogenase Similarly proximity effects have been suggested as responsible for the 10 fold increase in sensitivity of the coimmobilized system compared with a reaction scheme wherein aspartate amino transferase was immobilized and malate dehydrogenase was used in solution . L-Aspartate ~ oxaloacetate + NH~ oxaloacetate + NADH + H + -> malate + NAD +.
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