Advances in Immunology, Vol. 44 by Frank J. Dixon (Editor)

By Frank J. Dixon (Editor)

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Extra resources for Advances in Immunology, Vol. 44

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Are there positive selective forces favoring variants or is their establishment generally neutral? Is the process of variation itself selected? , 1985). , 1984). These values imply that MHC polymorphic regions are under relatively weak constraining pressures as to their exact protein sequence. Paradoxically, the absolute rate of evolutionary change between class I alleles and species homologs is actually less than that of most other genes analyzed, including the globins (Hayashida and Miyata, 1983).

The structural homology of these molecules suggests that they are displayed in a similar manner on the cell surface and probably interact with their ligands in a similar manner. If the CD8 molecule is typical of this group we would predict that the ligands for the CD7, CD28, and CTLA-4 proteins are superfamily members, perhaps even MHC or CD1 molecules. - - MOLECULES C. , 1985; Fig. 1). The murine Thy-1 molecule is found in abundance on thymocytes and neurons as well as fibroblasts and a variety of other cells.

This process helps mediate cooperation between the humoral and cellular immune pathways (Springer and Unkeless, 1984; Dickler, THE IMMUNOGLOBULIN GENE SUPERFAMILY 39 1982). , 1986). Two similar genes and alternate RNA processing are responsible for at least three different tissue-specific FcRy. Each has an external region composed mostly of two tandem homology units, a transmembrane region, and different cytoplasmic regions. The two homology units are more similar to each other than to any other Ig-like sequence, and hence are probably the result of an internal duplication.

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